CONGRATULATIONS to Prof. César Nombela-Arrieta for receiving an European Research Council Consolidator Grant !

The research of César Nombela-Arrieta, from the Department of Medical Oncology and Hematology at the University Hospital Zurich, explores the physiological mechanisms by which stem cell frequencies are controlled in bone marrow tissues. Hematopoietic stem cells sustain the continuous, life-long production of blood cells. In bone marrow tissues, the stem cell reservoir is constantly maintained, through a tightly regulated balance of stimuli that control stem cell proliferation, differentiation and quiescence. However, it is still unknown how the decisions of individual stem cells are coordinated to establish a collective cellular behavior that is geared towards preserving the entire stem cell pool. Nombela-Arrieta uses genetic tools and customised quantitative three-dimensional microscopy techniques to decrypt these complex forms of cellular communication. His research could help preserve the delicate balance of blood stem cells, which is perturbed in diseases such as cancer.

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